Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-215-4 | CAS number: 68475-94-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 October 2017 to 20 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 3 160 000
- Temp.:
- 30 °C
- pH:
- ca. 7
- Details on results:
- In the absence of any relevant dissociating functional groups, no specific manipulation of the mobile phase pH was necessary to ensure that the test item was evaluated in a non-ionized form. Therefore the determination was completed at an approximately neutral pH.
Due to the lack of significant chromophores in the test item structure, it was necessary to use different detector types, in series, to detect the deadtime and reference standards, and the test item. Due to the partition coefficient of the test item massively exceeding the highest reference standard, no correction for the internal volume (and hence retention time) between the two detectors was required during calculations. Also, it is acknowledged that the test item sample solution overloaded the ELSD on analysis; however this did not impact on the validity of the determination, since although no true peak maxima retention time was detected, it was only necessary to illustrate that the test item retention time exceeded that of DDT. - Conclusions:
- The partition coefficient of the test item has been determined to be greater than 6.50, log10 Pow >3.16 x 10e6.
Reference
Description of key information
Partition Coefficient (n-octanol/water). Greater than 3.16 x 106, log10Pow>6.5,determined using an HPLC method designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008andMethod 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.5
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
