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EC number: 231-303-8 | CAS number: 7488-56-4
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 24 May 2017 to 09 June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- Name: "Selenium Disulphide"
Chemical name: Selenium Disulphide
EC Number: 231 -303-8
CAS No: 7488-56-4
Batch No.: PMC / 285 / 16
Appearance: Orange powder
Purity: 100 %
Manufacturing date: 24 Nov 2016
Expiry/retest date: 3 years/ 24 Nov 2019
Conditions of storage: Dark place at room temperature (5°C - 30°C) - Key result
- Water solubility:
- < 0.5 mg/L
- Conc. based on:
- test mat.
- Remarks:
- Mean
- Temp.:
- 20 °C
- Remarks on result:
- not determinable because of methodological limitations
- Details on results:
- Preliminary test
Approximately forty-eight hours after starting of stirring there were still visible particles in thesolutions indicating a water solubility lower than 10 mg test item / L.
Main test
The temperature of the water bath was 20 °C at run A and B.
The pH of the solutions was 6.1 to 6.3 for run A and B.
The mean water solubility of "Selenium Disulphide" in water at 20 °C was:
< 0.50 mg / L, 8 replicates, at a flow of 25.0 ml / h and
< 0.50 mg I L, 8 replicates, at a flow of 12.5 ml / h.
The mean water solubility of run A and B of "Selenium Disulphide" in water at 20 °C was < 0.50 mg/L, 2 replicates.
In each replicate run the water solubility of the test substance was less than the limit of quantification (0.50 mg/L) of the analytical method. Due to the low water solubility the temperature coefficient of the solubility of the test substance cannot be determined, therefore no further tests at other temperatures were performed, in agreement with the guideline. - Conclusions:
- Selenium disulphide ihas been determined to be highly insoluble in water (< 0.50 mg/L at 20°C) at by the column elution method.
- Executive summary:
The objective of the study was to determine the water solubility of the test substance "Selenium Disulphide".
The water solubility of selenium disulphide was determined with the column elution method and quantified with ICP-AES in accordance with OECD Guideline No. 105 for the testing of chemicals, 27 July 1995.
In each of the replicates the water solubility of the test substance was less than the limit of quantification (0.50 mg/L at 20°C).
Due to the low water solubility the temperature coefficient of the solubility of the test substance cannot be determined, therefore no further tests at other temperatures were performed, in agreement with the guideline.
Therefore selenium disulphide can be determined to be highly insoluble in water (< 0.50 mg/L at 20°C)
Reference
Water solubility, run A, flow 25 ml/h, 20 °C
Sample |
Date/time |
Flow (mL/h) |
Total bed volume |
pH |
Sulphur content in water (mg/L) |
Test item concentration in water (mg/L) |
Deviation from the mean concentration (%) |
Start |
07.06.2017 11 :43 |
25 |
0 |
-- |
-- |
-- |
-- |
1 |
07.06.2017 14:25 |
25 |
27 |
6.2 |
< 0.225 |
< 0.50 |
-- |
2 |
07.06.2017 15:38 |
25 |
39 |
6.2 |
< 0.225 |
< 0.50 |
-- |
3 |
07.06.2017 16:51 |
25 |
51 |
6.2 |
< 0.225 |
< 0.50 |
-- |
4 |
08.06.2017 09:30 |
25 |
217 |
6.1 |
< 0.225 |
< 0.50 |
-- |
5 |
08.06.2017 10:47 |
25 |
230 |
6.2 |
< 0.225 |
< 0.50 |
-- |
6 |
08.06.2017 12:00 |
25 |
242 |
6.2 |
< 0.225 |
< 0.50 |
-- |
7 |
08.06.2017 13:16 |
25 |
255 |
6.1 |
< 0.225 |
< 0.50 |
-- |
8 |
08.06.2017 14:30 |
25 |
267 |
6.1 |
< 0.225 |
< 0.50 |
-- |
|
|
|
|
Mean: |
< 0.225 |
< 0.50 |
|
|
|
|
|
SD: |
-- |
-- |
|
Water solubility,run 8,flow 12.5 mUh, 20°C
Sample |
Date/time |
Flow (mL/h) |
Total bed volume |
pH |
Sulphur content in water (mg/L) |
Test item concentration in water (mg/L) |
Deviation from the mean concentration (%) |
Start |
07 06.2017 11 :43 |
12.5 |
0 |
-- |
-- |
-- |
-- |
1 |
07.06.2017 13:45 |
12.5 |
10 |
6.3 |
< 0.225 |
< 0.50 |
-- |
2 |
07.06.2017 16:08 |
12.5 |
22 |
6.2 |
< 0.225 |
< 0.50 |
-- |
3 |
08.06.2017 08:10 |
12.5 |
102 |
6.2 |
< 0.225 |
< 0.50 |
-- |
4 |
08.06.2017 10:36 |
12.5 |
114 |
6.1 |
< 0.225 |
< 0.50 |
-- |
5 |
08.06.2017 13:00 |
12.5 |
126 |
6.2 |
< 0.225 |
< 0.50 |
-- |
6 |
08.06.2017 15:20 |
12.5 |
138 |
6.3 |
< 0.225 |
< 0.50 |
-- |
7 |
09.06.2017 08:30 |
12.5 |
224 |
6.1 |
< 0.225 |
< 0.50 |
-- |
8 |
09.06.2017 11:20 |
12.5 |
238 |
6.2 |
< 0.225 |
< 0.50 |
-- |
|
|
|
|
Mean: |
< 0.225 |
< 0.50 |
|
|
|
|
|
SD: |
-- |
-- |
|
Analytical results
Analytical method: A method was validated to determine the content of sulphur in water to calculate the water solubility of the test item "Selenium Disulphide".
Linearity: The calibration curve was linear from the quantification limit up to the highest concentration of 5 mg S/L.
Detection limit: 0.013 mg S / L
Quantification limit: 0.045 mg S / L
Residual standard deviation: 9.2 cps
Method standard deviation: 0.015 mg S / L
Relative method standard deviation: 0.59%
Linearity
The calibration curve was linear from the quantification limit up to the highest concentration of 5 mg S/L.
The following function was received from the graph:
y[cps] = 624.79573[cps/(mgIL)]* x[mgIL] -7.96727 (cps]
where
x = nominal concentration of sulphur in mgIL
y = signal in counts persecond (cps)
with the following ranges respectively confidence intervals for slope and intercept of the linear function:
Slope: 622.9711 O-626.62036=624.79573±1.82463
lntercept: (-13.49161)-(-2.44293) = (-7.96727) ± 5.52434
Detection limit
0.013 mg SIL in the diluted samples, which corresponds to 0.15 mg test item IL calculated with a dilution factor of 5 (rounded to two significant digits).
Quantification limit
0.045 mg SIL in the diluted samples,which corresponds to 0.50 mg test item IL calculated with a dilution factor of 5 (rounded to two significant digits).
Residual standard deviation
The residual standard deviation was 9.2 counts per second (cps) in the diluted samples.
Method standard deviation
The method standard deviation was 0.015 mg S/L in the diluted samples.
Relative methodstandarddeviation
The relative method standard deviation was 0.59%.
Standard addition experiment
Sample |
Measured concentration without addition (mg S/L) |
Added concentration calculated (mg S/L) |
Measured concentration with addition (mg S/L) |
Added concentration measured (mg S/L) |
Recovery (%) |
Measurement 1 |
0.000 |
0.500 |
0.501 |
0.501 |
100 |
Measurement 2 |
0.001 |
0.500 |
0.503 |
0.503 |
101 |
Measurement 3 |
0.000 |
0.500 |
0.495 |
0.495 |
99 |
|
|
|
|
MEAN: |
100 |
Description of key information
Key value determined in a GLP accredited laboratory study using column elution method, in accordance with OECD Guideline 105 (Water Solubility)
Key value for chemical safety assessment
- Water solubility:
- 0.5 mg/L
- at the temperature of:
- 20 °C
Additional information
The objective of the study was to determine the water solubility of the test substance "Selenium Disulphide".
The water solubility of selenium disulphide was determined with the column elution method and quantified with ICP-AES in accordance with OECD Guideline No. 105 for the testing of chemicals, 27 July 1995.
In each of the replicates the water solubility of the test substance was less than the limit of quantification (0.50 mg/L at 20°C).
Due to the low water solubility the temperature coefficient of the solubility of the test substance cannot be determined, therefore no further tests at other temperatures were performed, in agreement with the guideline.
Therefore selenium disulphide can be determined to be highly insoluble in water (< 0.50 mg/L at 20°C)
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