Registration Dossier
Registration Dossier
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EC number: 616-968-8 | CAS number: 8015-92-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials: Chamomile oil Roman.
- Author:
- Opdyke DLJ
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology 12, 853.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Remarks:
- Testing carried out in 1973; predates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Butyl 2-methylcrotonate
- EC Number:
- 232-084-1
- EC Name:
- Butyl 2-methylcrotonate
- Cas Number:
- 7785-64-0
- Molecular formula:
- C9H16O2
- IUPAC Name:
- butyl (2E)-2-methylbut-2-enoate
- Reference substance name:
- 3-methylbutyl 2-methylbut-2-enoate
- Cas Number:
- 66917-62-2
- Molecular formula:
- C10H18O2
- IUPAC Name:
- 3-methylbutyl 2-methylbut-2-enoate
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 4 animals in total [sex unspecified]
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/4
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of Anthemis nobilis, ext., (Chamomile oil) in rabbits was > 5 g/kg bw.
- Executive summary:
The acute dermal toxicity of Anthemis nobilis, ext. (Chamomile oil), was evaluated using 4 rabbits [unspecified strain; unspecified sex ratio]. The rabbits were administered a single dose of 5 g/kg bw, and were then observed for 14 days. There were no mortalities. The dermal LD50 was reported to be > 5 g/kg bw.
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