Registration Dossier
Registration Dossier
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EC number: 202-354-3 | CAS number: 94-68-8
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: observation in humans
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other: safety data sheet
- Title:
- Safety data sheet - N-ethyl-2-methylaniline
- Author:
- Supplier of the substance
- Year:
- 2 014
Materials and methods
- Endpoint addressed:
- acute toxicity: inhalation
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
- Remarks:
- not relevant
Test material
- Specific details on test material used for the study:
- not specified
Method
- Ethical approval:
- not specified
- Exposure assessment:
- not specified
- Details on exposure:
- inhalation
Results and discussion
- Results:
- Clinical signs of intoxication in humans include methaemoglobinaemia and haematuria. An exposure of 40 ppm of toluidine (all isomers) in air for 60 minutes produces severe intoxication. Prolonged exposure to as little as 10 ppm was reported to cause symptoms of illness.
Applicant's summary and conclusion
- Conclusions:
- Clinical signs of intoxication in humans include methaemoglobinaemia and haematuria. An exposure of 40 ppm of toluidine (all isomers) in air tor 60 minutes produces severe intoxication. Prolonged exposure to as little as 10 ppm was reported to cause symptoms of illness.
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