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Registration Dossier
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EC number: 234-909-0 | CAS number: 12039-88-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Tungsten disilicide
- EC Number:
- 234-909-0
- EC Name:
- Tungsten disilicide
- Cas Number:
- 12039-88-2
- Molecular formula:
- Si2W
- IUPAC Name:
- Tungsten disilicide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 300 mg tungsten disilicide/kg body weight
2000 mg tungsten disilicide/kg body weight - No. of animals per sex per dose:
- 6 femakle rats/ 300 mg tungsten disilicide/kg body weight
6 female rats/ 2000 mg tungsten disilicide/kg body weight - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed in rats treated with 300 and 2000 mg Tungsten Disilicide/kg body weight.
- Clinical signs:
- other: No clinical sign was observed in all the rats treated with 300 and 2000 mg tungsten disilicide/kg body weight.
- Gross pathology:
- External
External examination of terminally sacrificed rats did not reveal any abnormality.
Internal
Visceral examination of terminally sacrificed rats did not reveal any abnormality.
In absence of any pathological lesion in terminally sacrificed rats, it is concluded that the test item did not produce any treatment related effect at the dose level used in the present study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- No mortality was observed in rats treated with 300 and 2000 mg tungsten disilicide/kg body weight. The acute oral LD50 (cut-off value) of tungsten disilicide in Wistar rats was found to be 5000 mg/kg body weight.
- Executive summary:
EXECUTIVE SUMMARY:In an acute oral toxicity study, four sets of fasted Wistar rats (3 females/set) (8 to 10 weeks) were given a single oral dose oftungsten disilicideat 300mg/kg body weight (set I and II) and 2000 mg/kg body weight (set III and IV) and all rats were observed for 14 days.
There were no treatment-related mortality, clinical sign and changes in body weight or necropsy findings observed.
The acute oral median lethal dose (LD50cut-off value) oftungsten disilicideinWistar rats was found to be 5000 mg/kg body weight.
Based on the results of this study, an indication of the classification fortungsten disilicideisas follows:
Globally Harmonized System of Classification and
Labelling of Chemicals (GHS 2017) : Category 5 or Unclassified
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