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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 May - 16 June 1994
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydroxyl-2-pyridone
EC Number:
212-506-0
EC Name:
Hydroxyl-2-pyridone
Cas Number:
822-89-9
Molecular formula:
C5H5NO2
IUPAC Name:
1-hydroxy-1,2-dihydropyridin-2-one
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study reports): Oxy PYRION
- Physical state: solid (powder)
- Appearance: white crystalline powder
Specific details on test material used for the study:
- Batch n°: 93100020
- Analytical purity: not reported
- Expiration date: not reported
- Storage condition: not reported

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
-0.489
Temp.:
25 °C
pH:
4.99
Remarks on result:
other: concentration 0.01M
Key result
Type:
log Pow
Partition coefficient:
-0.524
Temp.:
25 °C
pH:
4.99
Remarks on result:
other: concentration 0.001 M
Key result
Type:
log Pow
Partition coefficient:
-1.59
Temp.:
25 °C
pH:
7.02
Remarks on result:
other: concentration 0.01M
Key result
Type:
log Pow
Partition coefficient:
-1.47
Temp.:
25 °C
pH:
7.02
Remarks on result:
other: concentration 0.001 M
Key result
Type:
log Pow
Partition coefficient:
-2.73
Temp.:
25 °C
pH:
9.04
Remarks on result:
other: concentration 0.01M
Key result
Type:
log Pow
Partition coefficient:
-2.04
Temp.:
25 °C
pH:
9.04
Remarks on result:
other: concentration 0.001 M

Applicant's summary and conclusion

Conclusions:
The Pow value of the test item at 25°C and buffer pH 4.99 was 0.325 at 0.01M and 0.299 at 0.001M, corresponds to log Pow values of -0.489 and -0.524 respectively.
The Pow value of the test item at 25°C and buffer pH 7.02 was 0.0259 at 0.01M and 0.0336 at 0.001M, corresponds to log Pow values of -1.59 and -1.47 respectively.
The Pow value of the test item at 25°C and buffer pH 9.04 was 1.86E-03 at 0.01M and 9.05E-03 at 0.001M, corresponds to log Pow values of -2.73 and -2.04 respectively.