Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 926-119-6 | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Experimental adsorption coefficient studies have been performed on the two category members that are registered at >10 tpa. The experimental results were determined to be greater than 4.27 x 10 -5 (Log Koc >5.63) for both Reaction mass of 4,4'-methylenediphenyl diisocyanate and amines, soya alkyl (A003) and Polyurea, produced by reacting diphenylamine diisocyanate with octylamine and dodecylamine (R03). Based on these results, QSAR modelling and calculations were determined to be the most appropriate methods to fulfil the data requirement for all category members, as measured values are expected to be high and unbounded.
Koc values have been determined for the five substances being registered at >10 tpa that fit within the MDI category definition by calculation using the equation detailed in Technical Guidance Document on Risk Assessment Part III (EC, 2003) and by QSAR. The Log Koc values for the structures associated with these substances are in the range of 4.47 to 23.39.
Key value for chemical safety assessment
Additional information
MDI substances only occur in a base oil grease and, in realistic use scenarios, the formulated greases are specifically designed to minimise leaching of the thickener. The isolated thickeners are estimated to have water solubilities of less than 0.01 mg/L, vapour pressures of less than 10 E-10 Pa and high log octanol-water partition coefficients. On the basis of the physical-chemical properties and bioaccessibility studies, MDI substances are expected to reside within the grease base oil matrix. As such, MDI substances are not expected to partition to water, soil or air and hence are not anticipated to be accessible in the environment.
The adsorption coefficient values of two of the MDI category members registered at >10 tpa, Reaction mass of 4,4'-methylenediphenyl diisocyanate and amines, soya alkyl (A003) and Polyurea produced by reacting diphenylamine diisocyanate with octylamine and dodecylamine (R03), were estimated using the HPLC method in GLP-compliant studies conducted according to EU Method C.19 and OECD TG 121. The overall adsorption coefficient was determined to be greater than 4.27 x 105 (log Koc >5.63) for both A003 and R03. Based on the experimental results, it was confirmed that QSAR modelling and calculation methods are the most appropriate to fulfil this data requirement for all remaining substances in the category.
Therefore, Koc values have been determined for the five substances being registered at >10 tpa that fit within the MDI category definition, by calculation using the equation detailed in Technical Guidance Document on Risk Assessment Part III (EC, 2003) and by QSAR. The Log Koc values for the structures associated with these substances are in the range of 4.47 to 23.39.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
