Registration Dossier
Registration Dossier
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EC number: 220-278-9 | CAS number: 2698-41-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- NTP reference value
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- no guideline specified, but result considered by NTP as reliable
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- [(2-chlorophenyl)methylene]malononitrile
- EC Number:
- 220-278-9
- EC Name:
- [(2-chlorophenyl)methylene]malononitrile
- Cas Number:
- 2698-41-1
- Molecular formula:
- C10H5ClN2
- IUPAC Name:
- [(2-chlorophenyl)methylene]malononitrile
- Reference substance name:
- 1,1,1,3,3,3-hexamethyldisilazane
- EC Number:
- 213-668-5
- EC Name:
- 1,1,1,3,3,3-hexamethyldisilazane
- Cas Number:
- 999-97-3
- Molecular formula:
- C6H19NSi2
- IUPAC Name:
- 1,1,1-trimethyl-N-(trimethylsilyl)silanamine
- Reference substance name:
- Cab-0-Sil@ colloidal silica
- IUPAC Name:
- Cab-0-Sil@ colloidal silica
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Remarks:
- rats
- Effect level:
- ca. 88 480 other: mg.min/m3
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Remarks:
- mouse
- Effect level:
- ca. 50 010 other: mg.min/m3
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In rats, NTP (1990) reported LC50 by inhalation in male rats of 88 480 mg x min/m3 and in male mice of 50 010 mg x min/m3
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