Tris(isooctadecanoato-O)(propan-2-olato)titanium

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur

Reason / purpose for cross-reference:

data waiving: supporting information

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

according to guideline

Guideline:

other: DIN 38412 Part 11, Daphnia- Short term test

GLP compliance:

not specified

Analytical monitoring:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

> 10 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

yes

Conclusions:

The 24h EC50, flow though method, tesed on Daphnia magna was > 10000 mg/l for 2-propanol

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

10 000 mg/L

Additional information

No studies were conducted on the target substance. The target substance is hydrolytically unstable that, when coming into contact with water, it rapidly hydrolyzs to form 2-propanol, isostearic aicd and insoluble titanium dioxide. Therefore, the intrinsic toxicity of the target substance lies in the hydrolysis products.

The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.

Isostearic acid has very low water solubility (c.a. 0.597 mg/l at 20°C) and therefore exposure to the isostearic acid is unlikely.

2-propanol is practically miscible with water and therefore is taken into consideration. The 24h EC50 to Daphnia magna was > 10000 mg/l (Bringmann and Kühn, 1977). This value is used for CSA evaluation.