Registration Dossier
Registration Dossier
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EC number: 213-967-0 | CAS number: 1070-03-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other: QSAR report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- not required, QSAAR, see ducumentation in attached justifivation
- GLP compliance:
- no
- Type of assay:
- bacterial forward mutation assay
Test material
- Reference substance name:
- 2-ethylhexyl dihydrogen phosphate
- EC Number:
- 213-967-0
- EC Name:
- 2-ethylhexyl dihydrogen phosphate
- Cas Number:
- 1070-03-7
- Molecular formula:
- C8H19O4P
- IUPAC Name:
- 2-ethylhexyl dihydrogen phosphate
- Test material form:
- liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: QSAR
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- n.a.
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
- Remarks:
- QSAR
Results and discussion
Test results
- Key result
- Species / strain:
- other: all, QSAR
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
Applicant's summary and conclusion
- Conclusions:
- prediction of negative ames test by qsar
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