2H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl-

Guidance on Safe Use

First-aid measures

Ingestion: Never attempt to induce  vomiting. Do not attempt to give any solid or liquid by mouth  if the exposed subject is unconscious or semi-conscious. Wash out the mouth  with water.  If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation: Using appropriate personal protective equipment, move exposed subject to fresh  air. If breathing is difficult or ceases, ensure and  maintain ventilation.  Give oxygen  as appropriate. The exposed subject should  be kept warm and  at rest.  Obtain medical attention in cases of known or possible over exposure, or with symptoms including chest pain, difficulty breathing, loss  of consciousness or other  adverse effects, which may be delayed.

Skin Contact Using appropriate personal protective equipment, remove contaminated clothing and  flush exposed area with large  amounts of water.  Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

Eye Contact:

Wash immediately with clean  and  gently flowing water.  Continue for at least  15 minutes. Obtain medical attention

Fire-fighting measures

This material is non-combustible.

Dust clouds are potentially very highly sensitive to ignition from incendive electrostatic discharges.

Dust clouds are of very low sensitivity to ignition from hot surfaces. No ignition or exotherm of a powder layer observed up to 400 °C. Ignition of a dust cloud produces a strong dust explosion. High pressure between 8 and 10 bar is produced during a dust explosion.

Suitable Extinguishing media:

No special requirements needed.

Water is recommended for fires involving packaging.

Special Protective Equipment and Precautions for Fire Fighters

Since toxic, corrosive or flammable vapours might be evolved from fires involving this material, self contained breathing apparatus and full protective equipment are recommended for firefighters. Move containers from the fire area if possible without increased personal risk. If possible, contain and collect firefighting water for later disposal.

Specific Hazards arising from this material

Toxic, corrosive or flammable thermal decomposition products, which might include chlorine compounds, are expected when the material is exposed to fire

Accidental release measures

Personal Protection

Fence or cordon  the affected area and  do not allow individuals  to touch  or walk through  the spilled material  unless wearing  appropriate protective clothing. Avoid dust  generation.

Environmental Precautions

Prevent entry into waterways, sewers, surface drainage systems and  poorly ventilated areas. If spill is outdoors, cover with plastic  sheet to minimise  spreading or contact with rain.

Clean-Up Methods

Collect and  place  it in a suitable, properly  labelled container for recovery or disposal. After all solid or absorbent material  has  been collected, the area should  be vacuumed with HEPA

filter-equipped apparatus

Decontamination Procedures

No specific  decontamination or detoxification  procedures have  been identified for this material.

Consider use  of water,  detergent solutions, or other  soluble  solvents (if specified in Section 9 of

this SDS),  for clean-up and  decontamination operations.

Handling and storage

Avoid dispersion as a dust  cloud.

Depending upon  the scale of operation, use  of appropriate exhaust ventilation  is recommended to

provide routine  control of fire and  explosion hazards during handling of this material.

Ignition Controls

Bond and  earth  (ground)  all plant and  equipment to ensure that no isolated conductors are present. Isolated conductors can  accumulate sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules.

Consider earthing (grounding) personnel dealing  with dusty operations. An isolated (insulated) human body can  readily produce electrostatic discharges in excess of 50 mJ, but have  been recorded up to 100 mJ.

Minimise the use  of plastics when handling this material. Handle  and  store  this material  only in conductive or anti-static plastic  liners (bags) since normal  plastics are  known to be capable of producing electrostatic discharges of up to 4 mJ, ensuring that any containers into which they are placed are  themselves of a conductive material  and  earthed (grounded).

The maximum  surface temperature of enclosures potentially  exposed to this material  should  be the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust cloud or 75 K less  than  the minimum ignition temperature of the dust  layer, with a maximum temperature of 325 °C.

Protective Systems

Assess operations based upon  available dust  explosion information  to determine the suitability of preventive or protective systems as precautionary measures against possible dust  explosions. If prevention is not possible, consider protection by use  of containment, venting  or suppression of dust  handling equipment. Where explosion venting  is considered the most  appropriate method of protection, vent areas should  preferably be calculated based on the Kst rather  than  the St value. If nitrogen  purging  is considered as the protective system, it must  operate with an oxygen  level below the limiting oxygen  concentration.  The system should  include  an oxygen  monitoring and shut-down facility in the event  of excessive oxygen  being  detected.

At both ambient and  low humidity, this material  is of low conductivity.   Generation of electrostatic charge is considered likely to occur  even  when handled in an earthed (grounded) environment. At ambient humidity, this material  has  a very long charge relaxation time. Accumulation of electrostatic charge is considered very likely to occur  even  when handled in an earthed

(grounded) environment. Under  these conditions, it is considered that this material  might present a very high risk of producing an electrostatic discharge.

At low humidity, this material  has  an extremely long charge relaxation time. Accumulation of electrostatic charge will occur  even  when handled in an earthed (grounded) environment. Under these conditions, it is considered that this material  might present a very high risk of producing an electrostatic discharge.

Conditions for Safe Storage

Keep  in tightly closed containers or packages away from moisture and  away from sources of ignition.

Avoid prolonged storage at elevated temperatures (greater than  room temperature, approximately

20 degrees C).

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Exposure Controls

The hygiene guide for this material is >10 to 100 mcg/m3. An Exposure Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are assigned and how to interpret them.

Containment

Open handling is not recommended. Consider segregating operations, use of enclosures and sealed transfer systems.

Ventilation

Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a means of removing material incidentally released.

Administrative

Entry to the working area should be controlled. Doors with interlocks may be needed for materials airlocks and locker rooms. Only equipment and supplies necessary for job activities should be taken into working area.

Eye Protection Wear approved safety glasses with side shields or cover goggles if eye contact is possible.

Gloves The selection of gloves for a specific activity must be based on the material's properties and on possible permeation and degradation that may occur under the circumstances of use. Glove selection must take into account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised if insufficient data are available and further guidance should be sought from your local EHS department.

Respirators If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air concentrations present, required protection factor as well as hazards, physical properties and warning properties of substances present.

Stability and reactivity

Conditions to Avoid               Avoid direct sunlight,  conditions that might generate heat  and  dispersion as a dust  cloud

Disposal considerations

Collect for recycling  or recovery if possible. The recommended method of disposal is incineration.

Wherever possible, disposal should  be in an on-site  licenced chemical incinerator, if allowed  by

the incinerator licence or permit.   If no on-site  incinerator is available, dispose of material  in a licenced commercial chemical incinerator