Registration Dossier
Registration Dossier
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EC number: 233-514-0 | CAS number: 10210-68-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Sittig's Handbook of Toxic and Hazardous Chemical Carcinogens 6th ed.
- Author:
- Pohanish, R.P. (ed)
- Year:
- 2 012
- Bibliographic source:
- Pohanish, R.P. (ed). Sittig's Handbook of Toxic and Hazardous Chemical Carcinogens 6th Edition Volume 1: A-K,Volume 2: L-Z. William Andrew, Waltham, MA 2012, p. 742 as cited in HSDB
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not specified, handbook data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Octacarbonyldicobalt
- EC Number:
- 233-514-0
- EC Name:
- Octacarbonyldicobalt
- Cas Number:
- 10210-68-1
- Molecular formula:
- C8O8Co2
- IUPAC Name:
- 1,1,1,3,3,3-hexakis(oxidaniumylidynemethyl)-2,4-dioxo-1,3-dicobaltabicyclo[1.1.0]butane-1,1,3,3-tetrakis(ylium)
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- other: not specified
- Remarks on result:
- other: carbonyls are direct irritants; cobalt carbonyl is corrosive to the skin
Applicant's summary and conclusion
- Conclusions:
- carbonyls are direct irritants; cobalt carbonyl is corrosive to the skin
- Executive summary:
There is no available information on the methods used to determine the value for this endpoint. However, this information is taken from Sittig's Handbook which is considered to be a reliable peer reviewed handbook. Carbonyls are reported to be direct irritants; cobalt carbonyl is corrosive to the skin.
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