Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-667-7 | CAS number: 841-77-0
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 January - 04 May 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: isothermal thermogravimetry
- Specific details on test material used for the study:
- - Batch n°: M15BB1451
- Analytical purity: 98.8% (base titration)
- Expiration date: 30 January 2021
- Storage condition: at room temperature - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- <= 0.001 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- <= 0.002 Pa
- Conclusions:
- The isothermal TGA effusion method was applied for the measurement of the vapour pressure of JNJ-130806-AAA (T000750).
The vapour pressure of T000750 was determined to be <= 9.7 E-4 Pa (<= 7.3 E-6 mm Hg) at 20°C and <= 2.0 E-3 Pa (<=1.5 E-5 mm Hg) at 25°C.
Reference
Reference substances:
Validation of the method is performed at least once every year (project 512159).
Each reference substance was measured in duplicate by TGA using a temperature program that was specific for the substance. Plots of log vT obtained at elevated temperatures and 1/T were inter- or extrapolated to determine the log vT values at 20°C (log vT,20). The log vT,20 values were plotted against the logarithm of the vapour pressure at 20°C in Pascal units (log PT,20). Linear regression analysis using the least squares method yielded an equation of log PT,20= 1.14 x log vT,20 + 4.55. The coefficient of correlation (r) was > 0.99. The constants c and d specific for the experimental arrangement were 1.14 and 4.55, respectively.
Results:
From the plot of the log PT of the test item as a function of the reciprocal temperature the equation of the curve could be derived:
log PT= -5459 x 1/T + 15.61 (r = 0.997, n = 8). The results for the vapour pressure of the test item at 20°C and 25°C are:
| Temperature (°C) | log PT | PT (Pa) | PT (mm Hg) |
| 20 | -3.01 | 9.7 E-4 | 7.3 E-6 |
| 25 | -2.70 | 2.0 E-3 | 1.5 E-5 |
Description of key information
The vapour pressure of T000750 was assessed using the isothermal TGA effusion method, following the guidelines OECD 104, EU method A.4 and EPA OPPTS 830.7950 (K1, Brekelmans, 2017). The vapour pressure of T000750 was determined to be <= 9.7 E-4 Pa at 20°C and <=2.0 E-3 Pa at 25°C.
Key value for chemical safety assessment
- Vapour pressure:
- 0.001 Pa
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
