3,7,7-trimethylbicyclo[4.1.0]heptane-2-carbaldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22 august to 05 september 1989

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Study performed according to international guidelines without any deviation but not under GLP.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3,7,7-trimethylbicyclo[4.1.0]heptane-2-carbaldehyde

EC Number:

272-323-7

EC Name:

3,7,7-trimethylbicyclo[4.1.0]heptane-2-carbaldehyde

Cas Number:

68804-33-1

Molecular formula:

C11H18O

IUPAC Name:

3,7,7-trimethylbicyclo[4.1.0]heptane-2-carbaldehyde

Test material form:

liquid

Details on test material:

No confidential details

Test animals

Species:

rat

Strain:

other: IOPS (strain OFA SD)

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
Source: Elevage IFFA CREDO (69210 L'Arbresle, France)
Number and sex: 5 males treated and 5 males control
Housing: 5 animals per cage

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME ADMINISTERED: 2 g/kg

Doses:

2 g/kg

No. of animals per sex per dose:

5 males at 2 g/kg

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing
Clinical signs and mortality: Animals were observed for any behavioural or toxic effects at day -1, 0, 3 7 and 14 after administration of the item..
Bodyweight was recorded on Day-1, at day 0 after administration, and at day 3, 7 and 14
- Necropsy of survivors performed: Yes; On Day 15, animals were anaesthetised before a macroscopic examination.

Statistics:

None

Results and discussion

Preliminary study:

Not Applicable

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

>= 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other:

Mortality:

No death of animals was observed during 14 days of experimentation.
No organic or tissue lesion was observed during the autopsy.

Clinical signs:

Not applicable

Body weight:

Evolution of body weight of rats treated was comparable to control.

Gross pathology:

Not applicable

Other findings:

None

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The oral LD50 for 3,7,7-TRIMETHYLBICYCLO[4.1.0]HEPTANE-2-CARBOXALDEHYDE is higher than 2000 mg/kg.

Executive summary:

In an acute oral toxicity study (limit test) performed according to OECD Guideline 401, 5 male rats were given a single oral (gavage) dose of 3,7,7-TRIMETHYLBICYCLO[4.1.0]HEPTANE-2-CARBOXALDEHYDE at 2 g/kg. Animals were then observed for mortality, clinical signs and bodyweights for 14 days and were all sacrificed for macroscopic examination.

No death of animals was observed during 14 days of experimentation. No organic or tissue lesion was observed during the autopsy.

The oral LD50 for 3,7,7-TRIMETHYLBICYCLO[4.1.0]HEPTANE-2-CARBOXALDEHYDE is higher than 2000 mg/kg. Therefore, the substance is not classified according to CLP regulation (EU) No.1272/2008.