Registration Dossier
Registration Dossier
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EC number: 911-381-6 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxicity Studies on Selected Organosilicon Compounds: In Vitro Assays.
- Author:
- Isquith et al.
- Year:
- 1 988
- Bibliographic source:
- Fd Chem Toxic: 26, 255-261
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Octamethylcyclotetrasiloxane
- EC Number:
- 209-136-7
- EC Name:
- Octamethylcyclotetrasiloxane
- Cas Number:
- 556-67-2
- Molecular formula:
- C8H24O4Si4
- IUPAC Name:
- 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor induced rat liver S9
- Test concentrations with justification for top dose:
- 0.001 - 5.0 µl/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: abs. ethanol
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- not specified
Results and discussion
Test results
- Species / strain:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No mutagenic effect was observed in salmonella typhimurium strains used under the conditions of the test.
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