Registration Dossier
Registration Dossier
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EC number: 220-599-4 | CAS number: 2832-30-6
Endpoint summary
Administrative data
Description of key information
A subchronic feeding study was performed on male and female Wistar rats.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 81.4 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- scinetifically acceptable and sufficient documented for evaluation.
- System:
- other: body weight gain
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In a feeding study 15 male and 15 female rats received the test substance for 3 month in doses of 0 (control), 100, 1000 or 10000 ppm (male rats: 0, 8.34, 81.4, or 849,28 mg/kg bw/d; female rats: 0, 12.28, 121,32, or 1245,05 mg/kg bw/d). Animals were examined for mortality, body weight gain and clinical signs. A clinical-chemical, heamatological and urinalysis was peformed. A necropsy with a histopathological exmaination was done at the end of the study. Appearence and behaviour were unaffected. None of the animals died. No adverse effects were seen in haematology, clinical-chemistry and urinalysis. The body weight gain of the male rats was slightly retarded. In this context, the heart and testis weights of male rats were lower, but no histopathological effects were detected. Therefore these findings were regarded as toxicological not relevant. Pathology and histopathology were unobtrusive.
The NOAEL for male rats was 1000 ppm = 81.40 mg/kg bw/d and the NOAEL for female rats was 10000 ppm = 1245.05 mg/kg bw/d (highest applied dose).
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is not justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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