Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-704-8 | CAS number: 109-78-4
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study sufficient documented, meets generally scientific principles, acceptable for assessment No information about the control animals
Data source
Reference
- Reference Type:
- publication
- Title:
- Structure-activity|relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis.
- Author:
- Szabo S, Reynolds ES, Unger SH J
- Year:
- 1 982
- Bibliographic source:
- Pharmacol. Exp. Ther. 223: 68-75
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-hydroxypropiononitrile
- EC Number:
- 203-704-8
- EC Name:
- 3-hydroxypropiononitrile
- Cas Number:
- 109-78-4
- Molecular formula:
- C3H5NO
- IUPAC Name:
- 3-hydroxypropanenitrile
- Reference substance name:
- Ethylene cyanohydrin
- IUPAC Name:
- Ethylene cyanohydrin
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- female
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 4 days
- Frequency of treatment:
- 3 times daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
127 mmol/kg (9 g/kg)
- Control animals:
- other: no data specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Ulcerogenic index (sum of intensities of the individual
ulcers in each group divided by the total numbers of animals
per group): 0.8 (moderate)
Adrenocorticolytic index: 0 (no effect)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
