Tetrasodium 7,7'-(carbonyldiimino)bis[4-hydroxy-3-[(2-methyl-4-sulphonatophenyl)azo]naphthalene-2-sulphonate]

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

GLP compliance:

no

Remarks:

pre GLP

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Direct Orange 118

IUPAC Name:

Direct Orange 118

Test animals

Species:

rat

Sex:

male

Administration / exposure

Vehicle:

DMSO

Details on dermal exposure:

Gauze pads were soakedwith test item and fixed on the depilated dorsal skin of rats.
The treated skin areas were not washed off afterwards.

Duration of exposure:

4 hours

Doses:

5000 mg/kg

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

LD50 > 5000 mg/kg

Executive summary:

The dermal acute toxicity potential of the test item was assayed in rats. Gauze pads were soaked with test item and fixed on the depilated dorsal skin of rats. The bendage was removed after 4 hours and the treated skin areas were not washed off. Unfortunately, only a brief sheet of results is available, thus details about test procedures, results and test conditions are lacking. Therefore, a reliability cannot be assigned. The LD50 was indicated to be greater than 5000 mg/kg.