Dihydronicotinamide-adenine dinucleotide, disodium salt

Auto flammability

Administrative data

Endpoint:

relative self-ignition temperature (solids)

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

See further information in the cross-ref.

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 - 19 October 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria

Version / remarks:

Rev. 6 (2015)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: VDI 2263 Sheet 1 Grewer Oven

Version / remarks:

1990

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Key result

Test procedure:

other: Grewer oven

Remarks:

pure test item

Max. temp. reached:

225

Result:

other: temperature increase was observed starting at 160°C

Remarks on result:

other: on the basis of the results, the test item cannot be classified. Further tests are needed.

Key result

Test procedure:

other: Grewer oven

Remarks:

test item in mixture with Kieselguhr

Max. temp. reached:

200

Result:

other: temperature increase was observed starting at 170°C

Remarks on result:

other: on the basis of the results, the test item cannot be classified. Further tests are needed.

In the investigation of self-ignition in the Grewer Oven for the pure test item an exothermic process was detected starting at a temperature of approx. 160 °C that led to a maximum temperature of approx. 225 °C (corresponding oven temperature 180 °C). No further thermal effects could be observed up to the maximum test temperature of approx. 420 °C. After the measurement a swollen black residue remained in the wire basket.

For the test item in mixture with Kieselguhr a small exothermic process was detected starting at a temperature of approx. 170 °C that led to a maximum temperature of approx. 200 °C (corresponding oven temperature 185 °C). No further thermal effects could be observed up to the maximum test temperature of approx. 430 °C.

Interpretation of results:

study cannot be used for classification

Conclusions:

The pure test item Beta-NADH, disodium salt (CAS no. 606-68-8) indicated a self-heating at atmospheric pressure starting at a temperature of 160 °C. This self-heating process led to a maximum temperature of approx. 225 °C (corresponding oven temperature 180 °C). On the basis of the results of the tests on the self-ignition in the Grewer Oven according to the UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria, Appendix 6 Division 4.2, a classification of the test item as self-heating substance cannot be excluded. Further tests have to be performed for the classification.

Executive summary:

The pure test item Beta-NADH, disodium salt (CAS no. 606-68-8) indicated a self-heating at atmospheric pressure starting at a temperature of 160 °C. This self-heating process led to a maximum temperature of approx. 225 °C (corresponding oven temperature 180 °C). On the basis of the results of the tests on the self-ignition in the Grewer Oven according to the UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria, Appendix 6 Division 4.2, a classification of the test item as self-heating substance cannot be excluded. Further tests have to be performed for the classification.