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EC number: 249-670-8 | CAS number: 29508-47-2
Endpoint summary
Administrative data
Description of key information
Hydrolysis
The hydrolysis half life of test chemical 5-[[p-(benzylmethylamino)phenyl]azo]-1,4-dimethyl-1H-1,2,4-triazolium chloride (CAS: 29508-47-2) was estimated by Prediction is done using QSAR Toolbox version 3.3 with log kow as the primary discriptors. The Half life estimated is 229 d. Since, half life of hydrolysis of chemical 5-[[p-(benzylmethylamino)phenyl]azo]-1,4-dimethyl-1H-1,2,4-triazolium chloride (CAS: 29508-47-2) is more than 10 days it shows negligible hydrolysis in water.
Additional information
Hydrolysis
Following studies of target chemical and structurally similar read across includes predicted data and experimental data to conclude thehydrolysis of
5-[[p-(benzylmethylamino)phenyl]azo]-1,4-dimethyl-1H-1,2,4-triazolium chloride (CAS: 29508-47-2) is summarized below:
The hydrolysis half life of test chemical 5-[[p-(benzylmethylamino)phenyl]azo]-1,4-dimethyl-1H-1,2,4-triazolium chloride (CAS: 29508-47-2) was estimated by Prediction is done using QSAR Toolbox version 3.3 with log kow as the primary discriptors. The Half life estimated is 229 d. Since, half life of hydrolysis of chemical 5-[[p-(benzylmethylamino)phenyl]azo]-1,4-dimethyl-1H-1,2,4-triazolium chloride (CAS: 29508-47-2) is more than 10 days it shows negligible hydrolysis in water.
The above predicted data of target chemical is supported by the experimental study of structurally similar read across Methenamine (CAS: 100-97-0) from the publication Journal of pharmaceutical sciences 1980, suggests that thehydrolysis half life of test chemical Methenamine (CAS: 100-97-0) was determine as a function of pH. The Half life estimated is 6 h. Since, half life of hydrolysis of chemical Methenamine (CAS: 100-97-0) is more than 2 h it shows moderate hydrolysis in water. The conversion of methenamine is pH dependent.
The kinetics of degradation also were measured at 47, 57 and 67°C, and the reaction obeyed the Arrhenius relationship. At pH 2.0, the activation energy was calculated to be 23.5 kcal/mole; at pH 5.1, it was 12.0 kcal/mole.
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