Registration Dossier
Registration Dossier
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EC number: 240-715-7 | CAS number: 16669-59-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Guideline:
- other: 6-week feeding study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-[(2-methylpropoxy)methyl]acrylamide
- EC Number:
- 240-715-7
- EC Name:
- N-[(2-methylpropoxy)methyl]acrylamide
- Cas Number:
- 16669-59-3
- Molecular formula:
- C8H15NO2
- IUPAC Name:
- N-[(2-methylpropoxy)methyl]acrylamide
- Test material form:
- liquid
- Details on test material:
- A clear, light yellow, slightly viscous liquid with a pungent odour
Constituent 1
Test animals
- Species:
- rat
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 6 weeks
Doses / concentrationsopen allclose all
- Dose / conc.:
- 625 mg/kg bw/day (nominal)
- Dose / conc.:
- 1 250 mg/kg bw/day (nominal)
- Dose / conc.:
- 2 500 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- see attached full study report
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- see attached full study report
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 1 250 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
Target system / organ toxicity
- Key result
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 2 500 mg/kg bw/day (nominal)
- System:
- nervous system
- Organ:
- brain
- Treatment related:
- yes
- Dose response relationship:
- yes
- Relevant for humans:
- yes
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
