Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-675-9 | CAS number: 98-51-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The distribution of 14Cp-ter.-butyltoluene (TBT) following inhalation by the rat: A whole body autoradiographic study.
- Author:
- Ingebrigtsen K and Walde A
- Year:
- 1 982
- Bibliographic source:
- Acta pharmacol et toxicol 51: 203-208.
- Reference Type:
- publication
- Title:
- Metabolism of p-tert.-Butyltoluene in the Rat and Guinea Pig.
- Author:
- Walde A and Scheline RR
- Year:
- 1 983
- Bibliographic source:
- Acta Pharmacol Toxicol 53: 57-63.
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butyltoluene
- EC Number:
- 202-675-9
- EC Name:
- 4-tert-butyltoluene
- Cas Number:
- 98-51-1
- Molecular formula:
- C11H16
- IUPAC Name:
- 1-tert-butyl-4-methylbenzene
- Details on test material:
- (methyl-14C)p-tert-butyltoluene; according to the authors, radiochemical purity was 98-99%; no further data
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 14C
Test animals
- Species:
- other: rat, guinea pig
- Strain:
- other: Wistar (rat), Dunin Hartley (guinea pig)
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intragastric, inhalation
- Vehicle:
- not specified
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 3rd:
Any other information on results incl. tables
The elimination of the test substance after intragastric and inhalational administration (doses of 100 mg/kg) was studied in male Wistar rats and in male Dunkin Hartley guinea pigs.
The test substance was well absorbed through the gastro-intestinal and respiratory tract, was quickly distributed, and was eliminated within a few days.
In rats, 73% of a single oral dose (100 mg/kg) was recovered in the urine and feces within 3 days. After 10 days, 83% of the administered dose was recovered; the ratio of urinary/fecal radioactivity was ca. 3.5 : 1. Elimination was biphasic with the slower elimination phase beginning on day 6 after dosing.
At day 3 after dosing, urinary excretion of radioactivity was 45% and 25% after oral and inhalational exposure, respectively, in rats and 42% and 41% after oral and inhalational administration, respectively, in guinea pigs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
