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EC number: 203-115-6 | CAS number: 103-47-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-03-17 to 2016-05-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 191.4 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 1 - <= 3 d
- Temp.:
- 20 °C
- pH:
- ca. 2.9
- Water solubility:
- ca. 179.8 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 1 - <= 3 d
- Temp.:
- 10 °C
- pH:
- ca. 3
- Details on results:
- The preliminary test showed a water solubility of the test item of about 200g/L at 20 °C.
- Conclusions:
- The mean water solubility of the test item was determined to be 191.4 g/L at 20 °C (pH 3.0).
- Executive summary:
The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 by a validated HPLC.
The mean water solubility (three replicates over three days) was determined at 20°C as 191.4 g/L and at 10°C as 179.8 g/L. The mean pH of the solutions were 3.0 and 2.9, respectively.
Reference
Water solubility at 20°C:
| Equilibration time | measurement 1 | measurement 2 | measurement 3 | mean |
| Day 1 | 192.5 | 190.2 | 191.8 | 191.5 |
| Day 2 | 192.4 | 191.5 | 190.7 | 191.5 |
| Day 3 | 192.1 | 191.1 | 190.2 | 191.1 |
| overall mean | 191.4 | |||
| overall standard deviation | 0.24 |
|||
Description of key information
The mean water solubility of the test item was determined to be 191.4 g/L at 20 °C (pH 3.0) (reference 4.8 -1).
Key value for chemical safety assessment
- Water solubility:
- 191.4 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 by a validated HPLC.
The mean water solubility (three replicates over three days) was determined at 20 °C as 191.4 g/L and at 10 °C as 179.8 g/L. The mean pH of the solutions were 3.0 and 2.9, respectively.
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