Registration Dossier
Registration Dossier
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EC number: 408-090-7 | CAS number: 100418-33-5 METHYLGELB
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-((4-methyl-2-nitrophenyl)amino)ethanol
- EC Number:
- 408-090-7
- EC Name:
- 2-((4-methyl-2-nitrophenyl)amino)ethanol
- Cas Number:
- 100418-33-5
- Molecular formula:
- C9H12N2O3
- IUPAC Name:
- 2-[(4-methyl-2-nitrophenyl)amino]ethan-1-ol
- Test material form:
- solid: crystalline
- Details on test material:
- red powder
Constituent 1
- Specific details on test material used for the study:
- tested in a complex mixture
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- dermal
- Duration of treatment / exposure:
- 20 months
Results and discussion
Effect levels
- Remarks on result:
- other: no indication of causing skin or other tumours.
Applicant's summary and conclusion
- Conclusions:
- The study revealed no indication that Hydroxyethyl-2-nitro-p-toluidine, tested as part of non-oxidative hair dye formulation, might cause skin or other tumours in mice if dermally applied up to 20 months.
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