Bicyclo[2.2.1]heptanebis(methylamine)

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 August 2015 to 04 May 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Study conducted to OECD and EC guidelines and in compliance with GLP

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - Shake Flask Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

1

Temp.:

25 °C

Remarks on result:

other: no information on pH provided

Details on results:

A calibration plot of Log k versus Log Pow was constructed for the reference standards. The logarithm of the capacity factor for the test substance was then calculated and the Log Pow value was determined by interpolation. The substance was thus determined to have a Log Pow value of 1.0 (equivalent to a Pow value of 10).

HPLC determination of Log Pow for the substance

Sample	Component	tr (minutes)	k	Log k	Log Pow
Standard Run A (t0 = 1.425 minutes)	Acetanilide	1.674	0.175	-0.758	1.0
	Nitrobenzene	2.173	0.525	-0.280	1.9
	Ethylbenzoate	2.628	0.844	-0.074	2.6
	Bromobenzene	2.975	1.088	0.037	3.0
	Benzylbenzoate	3.282	1.303	0.115	4.0
	DDT	8.634	5.059	0.704	6.2
Sample A (t0 = 1.422 minutes)	Substance	1.765	0.241	-0.618	1.0
Sample B (t0 = 1.427 minutes)	Substance	1.770	0.240	-0.619	1.0
Standard Run B (t0 = 1.426 minutes)	Acetanilide	1.676	0.175	-0.756	1.0
	Nitrobenzene	2.174	0.525	-0.280	1.9
	Ethylbenzoate	2.630	0.844	-0.073	2.6
	Bromobenzene	2.977	1.088	0.036	3.0
	Benzylbenzoate	3.284	1.303	0.115	4.0
	DDT	8.640	5.059	0.704	6.2

Linear regression (based on mean of standard runs A and B): Log Pow = 3.68 Log k + 3.27

Conclusions:

The test material was found to have a Log Pow of 1.0

Executive summary:

The octanol-water partition coefficient was determined in a study which was conducted under GLP conditions and in accordance with the standardised guidelines OECD 117 and EU Method A.8 following the HPLC method.

Under the conditions of the study, the Log Pow of the substance was determined to be 1.0 at 25°C.

Description of key information

Log Pow: 1.0 at 25 °C, OECD 117, EU Method A.8, Envigo CRS Ltd (2016).

Key value for chemical safety assessment

Log Kow (Log Pow):

1

at the temperature of:

25 °C

Additional information

The octanol-water partition coefficient was determined in a study which was conducted under GLP conditions and in accordance with the standardised guidelines OECD 117 and EU Method A.8 following the HPLC method.

Under the conditions of the study, the Log Pow was determined to be 1.0 at 25 °C.