2-phenoxyethyl methacrylate

Biodegradation in water: screening tests

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The study is performed according to GLP and following OECD Guideline 301D, with no reported deviations. A 250 mg/l stock solution of the test substance could not be made, instead a 50 mg/l was prepared, this is beleived not to affect the results of the study.

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Oxygen conditions:

aerobic

Inoculum or test system:

sewage, domestic, non-adapted

Details on inoculum:

Secondary effluent collected at municipal waste water treatment plant, which primarily receives domestic sewage.

Duration of test (contact time):

28 d

Initial conc.:

2.5 mg/L

Based on:

test mat.

Parameter followed for biodegradation estimation:

O2 consumption

Details on study design:

test was run with test medium alone (inoculum control), test medium with test substance (test suspension), test medium with reference substance (activity control) and test medium with test and reference substance (toxicity control).

Reference substance:

benzoic acid, sodium salt

Parameter:

% degradation (O2 consumption)

Value:

22.3

Sampling time:

28 d

Results with reference substance:

The biodegradation of the reference substance sodium benzoate was 73.0% in 28 days, therefore the test can be considered valid.

Validity criteria fulfilled:

yes

Interpretation of results:

inherently biodegradable, fulfilling specific criteria

Conclusions:

The tested substance 2-phenoxyethyl acrylate cannot be considered readily biodegradable, on the basis of the results, as biodegradation of 22.3 % was observed in 28 days.

Executive summary:

A OECD Guideline study 301D was performed on 2 -phenoxyethyl acrylate according to GLP. The substance demonstrated a biodegradation of 22.3 % in 28 days, and can therefore not be considered readily biodegradable, as criteria for readily biodegradation is 60% in 28 days.

Reference 2

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Read-across from a OECD 301 study on one closely structural and physicochemical related substance: 2-Phenoxyethyl acrylate (M140).
For further read-across justification se document attached in section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Key result

Parameter:

% degradation (O2 consumption)

Value:

22.3

Sampling time:

28 d

Validity criteria fulfilled:

not applicable

Interpretation of results:

inherently biodegradable

Conclusions:

No data is available for 2-Phenoxyethyl methacrylate (T).
Biodegradation in water was performed on 2-phenoxyethyl acrylate in accordance with OECD Guideline study 301D. The substance demonstrated a biodegradation of 22.3 % in 28 days, and cannot be considered readily biodegradable, as criteria for readily biodegradation is 60% in 28 days.Based on read-across to other acrylates it was however concluded that 2-phenoxyethyl acrylate is at least inherently biodegradable.
Due to structural and physico-chemical similarity to 2-Phenoxyethyl acrylate, it can also be concluded for 2-Phenoxyethyl methacrylate that it is inherently biodegradable as well.

Executive summary:

No data is available for 2-Phenoxyethyl methacrylate (T).

Biodegradation in water was performed on 2-phenoxyethyl acrylate in accordance with OECD Guideline study 301D. The substance demonstrated a biodegradation of 22.3 % in 28 days, and cannot be considered readily biodegradable, as criteria for readily biodegradation is 60% in 28 days. Based on read-across to other acrylates it was concluded that

2-phenoxyethyl acrylate is at least inherently biodegradable.

Due to structural and physico-chemical similarity to 2-Phenoxyethyl acrylate, it can also be concluded for 2-Phenoxyethyl methacrylate that it is inherently biodegradable.

See justification for read-across attached in section 13.

Reference 3

Endpoint:

biodegradation in water: inherent biodegradability

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: QSAR based on good data for several substances in family

Justification for type of information:

QSAR based on data for several acrylates

Principles of method if other than guideline:

Read-across from other substances with structure similar to structure of test substance

GLP compliance:

yes

Remarks:

Assumed to be performed in accordance to GLP

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material:not relevant

Oxygen conditions:

not specified

Inoculum or test system:

not specified

Details on inoculum:

not relevant

Preliminary study:

Read-across to results from ready-biodegradabilty studies (OECD 301) for other similar substances showed that the test substance is most likely to be ready biodegradable. EpiSuite calculations support this. However, as the conclusion from ready-biodegradability test was that the substance is not readily biodegradable, it was assessed that a conservative conclusion from the read-across study is that the test substance is very likely to be at least inherently biodegradable.

Test performance:

Read-across

Remarks on result:

other: Not relevant, read-across

Details on results:

Read-across, so no %degradation is specified.

Results with reference substance:

not relevant

Validity criteria fulfilled:

not specified

Interpretation of results:

inherently biodegradable

Conclusions:

Based on the Read-across assessment the substance is concluded to be inherently biodegradable.

Executive summary:

Read-across to results from ready-biodegradabilty studies (OECD 301) for other similar substances showed that the test substance is most likely to be readily biodegradable. EpiSuite calculations support this. However, as the conclusion from ready-biodegradability test was that the substance is not readily biodegradable, it was assessed that a conservative conclusion from the read-across study is that the test substance is very likely to be at least inherently biodegradable.

Description of key information

No data is available for 2-Phenoxyethyl methacrylate (T).

Biodegradation in water was performed on 2-phenoxyethyl acrylate (S) in accordance with OECD Guideline study 301D. The substance demonstrated a biodegradation of 22.3 % in 28 days, and cannot be considered readily biodegradable, as criteria for readily biodegradation is 60% in 28 days.

Due to structural and pysico-chemical similarity to 2-Phenoxyethyl methacrylate, a biodegradation of 22.3 % in 28 days meaning that it is not readily biodegradable can also be concluded for 2-Phenoxyethyl methacrylate as well.

Key value for chemical safety assessment

Biodegradation in water:

inherently biodegradable, fulfilling specific criteria

Additional information

The pass-criteria for readily biodegradability test was not full-filled in the readily biodegradability test of 2-phenoxyethyl acrylate (S).However, read-across to other substances with similar structures and EpiSuite calculations strongly supports that 2-phenoxyethyl acrylate (S) should at least be inherently biodegradable, fulfilling specific criteria.

Due to structural and physico-chemical similarity to 2-Phenoxyethyl methacrylate, the same can also be concluded for 2 -Phenoxyethyl methacrylate as well.