Registration Dossier
Registration Dossier
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EC number: 233-242-2 | CAS number: 10099-70-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- May 08, 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See the attached justification
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish (Q)SAR Database
- Author:
- Danish EPA
- Year:
- 2 018
- Bibliographic source:
- Danish (Q)SAR Danish (Q)SAR database / (Q)SAR Models, Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, http://qsar.food.dtu.dk, https://qsarmodels.food.dtu.dk
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
- Principles of method if other than guideline:
- See the justification for type of information.
- GLP compliance:
- not specified
- Test type:
- other: in-silico
Test material
- Reference substance name:
- Diisopropyl maleate
- EC Number:
- 233-242-2
- EC Name:
- Diisopropyl maleate
- Cas Number:
- 10099-70-4
- Molecular formula:
- C10H16O4
- IUPAC Name:
- dipropan-2-yl (Z)-but-2-enedioate
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Reliability Index (RI)= 0.62
- Remarks:
- moderate prediction quality
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The oral median lethal dose (LD50) of diisopropyl maleate was estimated, with the ACD/Labs model for acute toxicity (LD50) in mice, as included in the Danish (Q)SAR Database, at 2200 mg/Kg bw.
- Executive summary:
The oral median lethal dose (LD50) of diisopropyl maleate was estimated, with the ACD/Labs model for acute toxicity (LD50) in mice, as included in the Danish (Q)SAR Database, at 2200 mg/Kg bw.
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