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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17.06.2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.82
Temp.:
25 °C
pH:
6.31
Conclusions:
The partition coefficient of the test substance Methylcentralit is: log P = 2.82 0.70 (25 °C, pH = 6.31)
Executive summary:

The partition coefficient of the test substance, Methylcentralit, was determined.

Based on the results of the preliminary estimation of the partition coefficient by a calculation method, the HPLC method was used for the main experiment.

The procedure was performed according to Method A.8. – Partition Coefficient,Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.

Partition coefficient (log P) of the test substance,Methylcentralit,is:

 

log P = 2.82 0.70 (25 °C, pH = 6.31)

Description of key information

Only one study is available.

Method A.8. – Partition Coefficient, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.

GLP study.

Klimish score 1.

Partition coefficient (log P) of the test substance, Methylcentralit is: log P = 2.82  (25 °C, pH = 6.31)

Key value for chemical safety assessment

Log Kow (Log Pow):
2.82
at the temperature of:
25 °C

Additional information