Ethyl cyano(hydroxyimino)acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Version / remarks:

Dec 17 2001

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Test material

Test material information

1

Reference substance name:

Ethyl cyano(hydroxyimino)acetate

EC Number:

223-351-3

EC Name:

Ethyl cyano(hydroxyimino)acetate

Cas Number:

3849-21-6

Molecular formula:

C5H6N2O3

IUPAC Name:

ethyl cyano(hydroxyimino)acetate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Doses:

300 mg/kg, 2000 mg/kg

No. of animals per sex per dose:

6 female animals 300 mg/kg, 3 female animals 2000 mg/kg

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

>= 300 - <= 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occured in groups 1F and 2F throughout the study period. All 3 animals in group 3F died shortly after dosing.

Clinical signs:

other: In group 1F (300 mg/kg), clinical signs were observed from 10 minutes after dosing. These included decreased motor activity, dyspnoea, piloerection, ventral recumbency, tremors, extension of forelimbs, loss of consciousness, tail elevatio and perinasal st

Gross pathology:

At the end of the 14-Day study period all animals in groups 1F and 2F were subjected to a full necroscopy following deaht. No pathological changes were noted in any of the animals. All animal in group 3F were subjected to a full gross necroscopy immediately following their death, and no pathological changes were noted in any of these animals.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

CLP classification is: H302 acute tox 4.
In view of the results obtained following a single PO adminsitration to Sprague-DawleyTM (SDTM) female rats, the GHS classification of the test iem xymapure is category 4 (LD50 of 300-2000 mg/kg).

Executive summary:

CLP classification is: H302 acute tox 4.

In view of the results obtained following a single PO adminsitration to Sprague-DawleyTM (SDTM) female rats, the GHS classification of the test iem xymapure is category 4 (LD50 of 300-2000 mg/kg).