Registration Dossier
Registration Dossier
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EC number: 241-045-8 | CAS number: 16969-10-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- QSAR for dermal permeability coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Dermwin (v 2.01) in Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11.
- Author:
- US EPA, United States Environmental Protection Agency, Washington, DC, USA.
- Year:
- 2 017
- Bibliographic source:
- https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface#models
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- The Dermal Permeability Coefficient Program (DERMWIN) v2.00 estimates the dermal permeability coefficient (Kp), the dermally absorbed dose per event (DAevent) and Dermal Absorbed Dose (DAD) of organic compounds via water contact.
Test material
- Reference substance name:
- 2-hydroxy-3-phenoxypropyl acrylate
- EC Number:
- 241-045-8
- EC Name:
- 2-hydroxy-3-phenoxypropyl acrylate
- Cas Number:
- 16969-10-1
- Molecular formula:
- C12H14O4
- IUPAC Name:
- 2-hydroxy-3-phenoxypropyl acrylate
Constituent 1
- Specific details on test material used for the study:
- SMILE: O=C(C(=COc1ccccc1)O)OCCC
Results and discussion
Percutaneous absorption
- Parameter:
- rate
- Remarks:
- kp
- Absorption:
- 0.002 cm/h
- Remarks on result:
- other: dermal permeability coefficient
Applicant's summary and conclusion
- Conclusions:
- Based on DERMWIN, the Kp of 2-hydroxy-3-phenoxypropyl acrylate is 0.00198 cm/hr.
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