Registration Dossier
Registration Dossier
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EC number: 606-423-2 | CAS number: 200295-52-9
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential to cause toxic effects if accumulated (in higher organisms) via the food chain
Additional information
Conclusion on classification
The registered substance is highly insoluble in water (< 0.1 mg/L) and no effects to the three trophic levels have been identified up to 100 mg/L. Further the substance is not readily biodegradable but is unlikely to have a potential for bioaccumulation.
A study of bioaccumulation in aquatic species does not need to be conducted as direct or indirect exposure of the aquatic compartment is unlikely (Anney IX, Column 2). LogKow of 8.6 indicates a high potential for bioaccumulation. However, no effects have been identified neither regarding the aquatic toxicity nor the oral toxicity or the repeated dose testing. Furthermore the molecular weight of >700 g/mol and the very branched structure of the molecules indicates that the substance is unlikely to bioaccumulate (Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.11). The diameter of the molecule can be another indicator for bioaccumulation (Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.11).
There are several drawing programs with which the diameter of a molecule can be calculated. According to MarvinSketch 16.10.10.0 the minimal diameter of BL IPDI Trimer is >2.0 nm in its lowest energy 3D-Configuration. The 3D-Configuration is calculated based on the Dreiding force field (Mayo et al., 1990). Thus it is unlikely to biaccumulate according to a BCF base-model (Dimitrov et al., 2005), which gives 1.7 nm as a cut-off value. If molecules have bigger diameters the probability to cross the cell membrane decreases significantly.
As a conclusion to the results listed above the substance does not have to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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