Registration Dossier
Registration Dossier
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EC number: 202-433-2 | CAS number: 95-57-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
- Remarks:
- (no details on study design and results provided)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To evaluate irritating properties towards the skin, the test substance was topically applied to the skin of six rabbits for 4 and 24 h. Local reactions were scored at 4, 24, 48, 72 und 168 h.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-chlorophenol
- EC Number:
- 202-433-2
- EC Name:
- 2-chlorophenol
- Cas Number:
- 95-57-8
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 2-chlorophenol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Lot/batch No.of test material: KL 1003
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- Duration of treatment / exposure:
- 4 and 24 h
- Observation period:
- 21 days
Reading time points: 4, 24, 48, 72 and 168 h and daily afterwards until day 21 - Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: erythema
- Basis:
- animal: 1 - 6
- Time point:
- other: 4 h
- Reversibility:
- not reversible
- Remarks on result:
- other: severe erythema were observed (no scores given).
- Irritation parameter:
- other: edema
- Basis:
- animal: 1-6
- Time point:
- other: 4 h
- Reversibility:
- not reversible
- Remarks on result:
- other: severe edema were observed.
- Irritant / corrosive response data:
- Topical application for 4 h resulted in severe erythema and edema. When the test substance was applied for 24 h, eschar formation was observed. Loosening about edges of scab after 17 - 21 days showed injury in depth.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- CLP: Category 1
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