Registration Dossier
Registration Dossier
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EC number: 205-130-3 | CAS number: 134-11-2
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 6.3 days to 1.4 yrs, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.
Additional information
Hydrolysis
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The hydrolysis half-life of the test chemical was determined. The study was performed at pH 3.5, 5.0, 7.4, 9.5 and 11.3 & at a temperature of 17⁰C, respectively. The half-life value of test chemical was determined to be 12.5 days, 5.4 days, 6.3 days, 2.2 days and 1.2 hrs with a corresponding hydrolysis rate constant of 0.00000065/sec, 0. 0000015/sec, 0. 0000013/sec, 0. 0000037/sec & 0. 00064/sec at pH 3.5, 5.0, 7.4, 9.5 and 11.3 & at a temperature of 17⁰C, respectively. Based on the half-life value (i.e, 6.3 days at pH 7.4), it is concluded that the test chemical is slowly hydrolysable in water.
In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
For the test chemical, the hydrolysis half-life was determined. The study was performed at pH 5, 7 and 9, respectively. The half-life value of test chemical was determined to be > 30 days at pH 5, 7 and 9, respectively. Based on this half-life value, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 6.3 days to 1.4 yrs, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.
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