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EC number: 700-220-3 | CAS number: 99636-32-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Only one study is available (BASF SE, 1999; Study report number 31S0269/98053) performed according to the OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity in Rodents).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
Additional information
In the OECD guideline 407 study S-MOIPA was administered to groups of 5 male and 5 female Wistar rats by gavage for 4 weeks at doses of 0, 30, 100 and 300 mg/kg body weight/day. The vehicle used was aqua bidest and the administration volume was 10 ml/kg from day 0 to 14, and 20 ml/kg from day 15 to day 27. Food consumption and body weight were determined weekly. The animals were examined for signs of toxicity or mortality at least once a day. Additionally, general clinical observations were carried out before daily treatment, less than 1 hour after treatment and between 3 and 4 hours after treatment. Detailed clinical observations in an open field were conducted prior to the start of the administration period and weekly thereafter. Functional observational batteries (FOBs) and motor activity measurements were carried out after 4 weeks of treatment. Clinicochemical, hematological examinations and urinalyses were carried out towards the end of the administration period. All animals were assessed by gross pathology, followed by histopathological examinations.
The following substance-related effects were obtained:
- 300 mg/kg body weight: One female died on day 12; Abnormal clinical signs were observed on different days of the study such as reddish smeared snout region or red smeared nose, urine smeared anogenital region, salivation after treatment, respiratory sounds, abdominal respiration, labored respiration, and/or piloerection.
- 100 mg/kg body weight: No substance-related effects
- 30 mg/kg body weight: No substance-related effects
Thus, toxic effects were seen at the high dose level, only. These findings were most probably related to a local affection of the upper digestive tract and/or general toxicity. The no observed adverse effect level (NOAEL) under the conditions of this study was 100 mg/kg for both sexes.
The substance causes burns. Therefore, local effects seem to be the dominant toxicological effects.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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