Calcium dodecylbenzenesulphonate

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

yes

Analytical monitoring:

not specified

Vehicle:

yes

Test organisms (species):

Cyprinus carpio

Details on test organisms:

SPECIES #
(NAME): 21 Cyprinus carpio
(Common Carp)
AGE: NR
LIFE STAGE: not reported, unknown
COMMENT: 5.5 CM, 1.8 G

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Hardness:

18mg/L

Test temperature:

21±1.8℃

pH:

7.1±0.2

Dissolved oxygen:

6.5-8.4ppm

Reference substance (positive control):

not specified

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

2.8 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

4.2 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

yes

Conclusions:

Under static conditions the LC50 in Cyprinus carpio was between 2.8 mg/l and 4.2 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

EPI Suite v 4.1/ECOSARv1.00

GLP compliance:

no

Remarks:

not applicable to QSAR models

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: Fishes species

Details on test organisms:

no further information

Test type:

other: QSAR model

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Hardness:

not applicable. QSAR model

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Dissolved oxygen:

not applicable. QSAR model

Salinity:

not applicable. QSAR model

Details on test conditions:

100% : Benzenesulfonic acid, dodecyl-, calcium salt
CAS Number: 26264-06-2
SMILES : CCCCCCCCCCCCc1ccc(S(=O)(=O)OOS(=O)(=O)c2ccc(CCCCCCCCCCCC)cc2)cc1
CHEM : Benzenesulfonic acid, dodecyl-, calcium salt
MOL FOR: C36 H58 O6 S2 Ca1
MOL WT : 691.06
Wat Sol: 0.006264 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Log Kow: 4.770
Remarks: Anionic surfactant – alkyl benzene sulfonates; effective alkyl chain length = C12

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

1.74 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

not specified

Details on results:

Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 1.74 mg/l was established.
Fish, 96-hr LC50 =1.74 mg/L (ppm)

Results with reference substance (positive control):

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for chemicals properties assessment.

Conclusions:

Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 1.74 mg/l was established.
Fish, 96-hr LC50 =1.740 mg/L (ppm)
Fish 30-day ChV = 0.230mg/L (ppm)

Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.

Description of key information

Under static conditions the LC50 in Cyprinus carpio was between 2.8 mg/l  and 4.2 mg/l  for Calcium dodecylbenzenesulphonate which is moderate toxicity .
Under static conditions the LC50 in Oryzias latipes  was between 3 mg/l  and 5.3 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .
Under static conditions the LC50 in Misgurnus anguillicaudatus   was between 3.3 mg/l  and 6 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.
The available data for saltwater fishes a are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

2.8 mg/L

Marine water fish

Marine water fish

Effect concentration:

0.28 mg/L

Additional information

Under static conditions the LC50 in Cyprinus carpio was between 2.8 mg/l and 4.2 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .

 

Under static conditions the LC50 in Oryzias latipes was between 3 mg/l and 5.3 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .

 

Under static conditions the LC50 in Misgurnus anguillicaudatus  was between 3.3 mg/l and 6 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .

 

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.

 

The available data for saltwater fishes a are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa