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EC number: 931-468-2 | CAS number: 1190625-94-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96 h LC50 exceeded a WSF prepared at a loading rate of 100 mg/L (Cyprinus carpio), OECD 203, EU Method C.1, ISO Standard 7346-1 (Part 1) and OECD 23.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
In the key study, the toxicity of the test material to Carp (Cyprinus carpio) was investigated in accordance with the standardised guidelines OECD 203, EU Method C.1, ISO Standard 7346-1 (Part 1) and OECD 23 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the principles for assessing data quality set forth by Klimisch et al. (1997).
The batch of material tested was completely soluble in test medium at the concentrations tested. Preparation of test solutions for the limit test started with the test concentration of 100 mg/L, applying two days of magnetic stirring to ensure reaching maximum saturation followed by a 21.5 hour settlement period. The clear and colourless Water Soluble Fraction (WSF) was then collected by means of siphoning.
A final test was performed as a limit test based on the result of a preceding range-finding test. Seven carp per test group were exposed for 96 hours to an untreated control group and to a WSF prepared at a loading rate of 100 mg/L. Samples for analytical confirmation of actual exposure concentrations were taken at the start and the end of the test period.
Analysis of the samples taken at the start and the end of the limit test showed measured concentrations of 27 and 11 µg/L, respectively. The average measured concentration corresponded with 17 µg/L, which is close to the actual water solubility of 26 µg/L.
No toxicity was observed in this study at the concentrations tested. The study met the acceptability criteria prescribed by the protocol and was considered valid.
Under the conditions of this study, the 96 h LC50 exceeded a WSF prepared at a loading rate of 100 mg/L.
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