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EC number: 203-672-5 | CAS number: 109-43-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: > 80 (CO2 evolution) in 28 days (OECD 301B), read across
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Since no studies investigating the ready biodegradability of Dibutyl sebacate (CAS 109-43-3) are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Diisopropyl sebacate (CAS 7491-02-3) and Di(2-ethylhexyl) sebacate (CAS 122-62-3) was conducted in a weight-of-evidence approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.
The study with Diisopropyl sebacate (CAS 7491-02-3) was conducted according to OECD guideline 301B under aerobic conditions using non-adapted activated sludge as inoculum (Defleur, 1998). A mean degradation of 89.6% was observed after 28 days and the 10-day-window was passed. Hence, the substance is determined to be readily biodegradable according to OECD criteria.
The study with Bis(2-ethylhexyl) sebacate (CAS 122-62-3) was conducted according to OECD 301B under aerobic conditions using non-adapted activated sludge, from a STP which predominately treats domestic sewage, as inoculum (Defleur, 1998). Based on CO2 evolution a degradation of 84.6% was observed after 28 days and the 10-day window was passed. Hence, the substance is determined to be readily biodegradable according to OECD criteria. A QSAR calculation for Dibutyl sebacate (CAS 109-43-3) using BIOWIN v4.10 resulted in the prediction of ready biodegradability and thus confirmed the results of the source substances (Hopp, 2011).
Due to structural similarities with the tested category members these results are also applicable to read across to Dibutyl sebacate (CAS 109-43-3). Hence, Dibutyl sebacate can be classified as readily biodegradable according to OECD criteria.
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