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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Controls:
not required
Duration of treatment / exposure:
100 mg was introduced into the left conjunctival sa. during the hole observation period for 72 hours.
Observation period (in vivo):
24 hour
48 hour
72 hour
1 hour
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24h 48h 72h
Score:
<= 1
Max. score:
1.3
Reversibility:
fully reversible
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24h 48h 72h
Score:
<= 1.9
Max. score:
2.7
Reversibility:
fully reversible
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24h 48h 72h
Score:
<= 2
Max. score:
2.3
Reversibility:
fully reversible
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24h 48h 72h
Score:
<= 0.3
Max. score:
0.7
Reversibility:
fully reversible

Applicant's summary and conclusion

Interpretation of results:
other: very slight irritation
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The test item is not eye irritant