Registration Dossier
Registration Dossier
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EC number: 206-557-8 | CAS number: 354-33-6
Endpoint summary
Administrative data
Description of key information
LC50 > 800000 ppm (3927000 mg/m3)
Key value for chemical safety assessment
Additional information
In an OECD guideline study (Nakayama et al., 1992a), 10 Sprague Dawley rats (5 males and 5 females) were exposed to 800000 ppm (3927000 mg/m3) HFC-125 in atmosphere for 4 hours. Another 10 animals were exposed to normal air for control. No mortality was observed within 14 days after the exposure. During the exposure, clinical signs typical of an anaesthetic effect, such as abnormal respiration and ataxic gait, were observed. These effects disappeared within 1 hour after the end of the exposure period. A slight decrease in mean body weight was registered in the exposed males, in comparison with the control males. No remarkable findings were observed during the autopsy. The lowest lethal dose (LDLo) was > 800000 ppm (highest dose tested) for this study.
In another study (Panepinto, 1990), 6 Sprague Dawley rats/group were exposed to 503000 and 709000 ppm HFC 125 No mortality or significant clinical signs were noted in the study. Transient body weight losses were recorded on day 1 of the recovery period, but a general body weight gain was observed in rats at the end of the recovery period. An ALC greater than 709000 ppm (3480 g/m3) was established under this test conditions.
Justification for classification or non-classification
No lethality or significant toxicity were observed up to 800000 ppm. No classification is deemed necessary
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