Registration Dossier
Registration Dossier
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EC number: 266-946-3 | CAS number: 67701-28-4 This substance is identified by SDA Substance Name: C8-C18 and C18 unsaturated trialkyl glyceride and SDA Reporting Number: 01-001-00.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 7 500 mg/kg bw/day
Additional information
No reproductive toxicity
Effects on developmental toxicity
Description of key information
No developmental toxicity
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 7 500 mg/kg bw/day
Justification for classification or non-classification
‘Glycerides, C8-18 and C18-unsatd. (SDA Reporting Number: 01-001-00)’ and other substances of the same read-across category have been tested for reproductive toxicity in rodents and found to have no effect after oral exposure. No reproductive toxicity is expected from dermal exposure as systemic uptake will be lower than from the oral route. Finally, given the physical state, low vapour pressure of the substance and the fact that it is not handled or marketed as a liquid or a powder, reproductive toxicity as a result of inhalatory exposure is not expected.
‘Glycerides, C8-18 and C18-unsatd. (SDA Reporting Number: 01-001-00)’ and other substances of the same read-across category have a very long history of safe use in nutritional (food and feed), cosmetic and industrial applications. In the form of olive oil, corn oil, sunflower oil, etc., they are also frequently employed as vehicles in toxicity studies following international testing guidelines (e.g. OECD) for the evaluation of the repeated dose toxicity, carcinogenicity or reproductive/developmental toxicity of chemical substances, without any apparent adverse effects.
Based on the existing information, the substance does not require classification for reproductive or developmental toxicity according to Directive 67/548/EC or Regulation 1272/2008/EC.
Additional information
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