Registration Dossier
Registration Dossier
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EC number: 701-374-4 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: model results
- Title:
- EPISUITE 4.0 Report on Diisodecylpheny Phosphite (DDPP; CAS 25550-98-5)
- Author:
- US EPA
- Year:
- 2 009
- Bibliographic source:
- US EPA
- Report date:
- 2009
- Reference Type:
- other: model result
- Title:
- EPISUITE 4.0 Report on Triisodecyl Phosphite (TDP; CAS 25448-25-3)
- Author:
- US EPA
- Year:
- 2 010
- Bibliographic source:
- US EPA
- Reference Type:
- other: model result
- Title:
- EPISUITE 4.0 Report on Diphenyl isodecyl Phosphite (DPDP; CAS 26544-23-0)
- Author:
- US EPA
- Year:
- 2 010
- Bibliographic source:
- US EPA
Materials and methods
- Principles of method if other than guideline:
- Modeled results using EPISUITE 4.0 (BCFBAF v.3.00) for the 3 constituent chemicals of the substance - diisodecylphenyl phosphite (DDPP), triisodecyl phosphite (TDP), and diphenyl isodecyl phosphite (DPDP).
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- EC Number:
- 701-374-4
- Cas Number:
- 25550-98-5
- Molecular formula:
- C26H47O3P
- IUPAC Name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- Details on test material:
- 3 constituent chemicals of the substance - diisodecylphenyl phosphite (DDPP), triisodecyl phosphite (TDP), and diphenyl isodecyl phosphite (DPDP).
Constituent 1
Results and discussion
Bioaccumulation factor
- pH:
- 7
- Type:
- BCF
- Value:
- 606.5 L/kg
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
-------------------------------- BCFBAF v3.00 --------------------------------
DDPP Results
Summary Results: Log BCF (regression-based estimate): 2.39 (BCF = 245 L/kg wet-wt)
Biotransformation Half-Life (days) : 27.6 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 4.21 (BAF = 1.63e+004 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 9.32
Equation Used to Make BCF estimate: Log BCF = -0.49 log Kow + 7.554 + Correction Correction(s): Value Alkyl chains (8+ -CH2- groups) -0.596 Estimated
Log BCF = 2.389 (BCF = 244.7 L/kg wet-wt)
--------------------------------- BCFBAF v3.00 --------------------------------
TDP Results
Summary Results: Log BCF (regression-based estimate): 1.52 (BCF = 33.3 L/kg wet-wt)
Biotransformation Half-Life (days) : 230 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 2.71 (BAF = 509 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 12.31
Equation Used to Make BCF estimate: Log BCF = -0.49 log Kow + 7.554 + Correction (no use)
Log BCF = 1.522 (BCF = 33.27 L/kg wet-wt)
-------------------------------- BCFBAF v3.00 --------------------------------
DPDP Results
Summary Results: Log BCF (regression-based estimate): 2.78 (BCF = 607 L/kg wet-wt)
Biotransformation Half-Life (days) : 15.5 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): 4.38 (BAF = 2.4e+004 L/kg wet-wt)
Log Kow (experimental): not available from database
Log Kow used by BCF estimates: 8.52
Equation Used to Make BCF estimate: Log BCF = -0.49 log Kow + 7.554 + Correction Correction(s): Value Alkyl chains (8+ -CH2- groups) -0.596 Estimated
Log BCF = 2.783 (BCF = 606.5 L/kg wet-wt)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- BCFs of 33.27 to 606.5 L/kg wet weight were calculated using the BCFBAF v3.0 program. This model use the log Kow in the following equation: Log BCF = -0.49 log Kow + 7.554 + Correction (varies).This substance does not meet the bioaccumulation criteria (BCF) of 2000 L/kg. Therefore, it is not a PBT.
- Executive summary:
BCFs of 33.27 to 606.5 L/kg wet weight were calculated using the BCFBAF v3.0 program. This model use the log Kow in the following equation: Log BCF = -0.49 log Kow + 7.554 + Correction (varies).
This result is likely to overpredict the bioaccumulation potential of these phosphites given the size and molecular weight of the molecules and also due to the fact that it is not clear that the model is valid at such a high Kow value. Regardless, the predicted values are well below the PBT criterion on 2000 L/kg. Further, these results do not consider the fact that this substance rapidly hydrolyses and that the hydrolysis products have a low bioaccumulation potential and a readily biodegradable.
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