Registration Dossier
Registration Dossier
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EC number: 203-442-4 | CAS number: 106-92-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: 3 days
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary report
Data source
Reference
- Reference Type:
- publication
- Title:
- Actions & interactions: Glycidyl ethers.
- Author:
- Lane JM
- Year:
- 1 980
- Bibliographic source:
- Veterinary and human toxicology 22(2): 99-101
Materials and methods
- Principles of method if other than guideline:
- Male rats were exposued to allyl glycidyl ether via intramuscular injections (400 mg/kg bw) on 3 consecutive days and subjected to lymphoid tissue examination.
- Limit test:
- yes
Test material
- Reference substance name:
- Allyl 2,3-epoxypropyl ether
- EC Number:
- 203-442-4
- EC Name:
- Allyl 2,3-epoxypropyl ether
- Cas Number:
- 106-92-3
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2-[(prop-2-en-1-yloxy)methyl]oxirane
- Details on test material:
- - Name of test material (as cited in study report): Allyl Glycidyl Ether
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- intramuscular
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
2 out of 3 showed atrophy or loss of lymphoid tissue and decreased leucocyte count. The same report summarized results for other glycidyl ethers showing similar results indicating a class effect.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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