Dibutyltin dichloride

Short-term toxicity to fish

Description of key information

The following studies have been submitted for the short-term toxicity to fish endpoint:
Hooftman RN and De Wolf JM (2003a). Dibutyldichlorostannane (CAS # 683-18-1): Semi-static acute toxicity test with the zebra fish Brachydanio rerio. Testing laboratory: TNO, Project Organisation, Ecotoxicology, Utrechtseweg 48, P. O. Box 370, 3700 AJ Zeist, The Netherlands. Report no.: V2495/03. Owner company: Organotin Environmental Programme (ORTEP) Association, Stabilizer Task Force. Study number: 01-2495/03. Report date: 2003-10-03.
Nagase H et al (1991). Structure-activity relationships for organotin compounds on the red killifish Oryzias latipes. APPLIED ORGANOMETAL. LIC CHEMISTRY. VOL. 5, 91-97.
Steinhaüser K et al (1985). Investigations on the Aquatic Toxicity of Organotin Compounds. Vom Wasser, 65: 203-214.
Hooftmann and De Wolf (2003a) has been allocated a Klimisch score of 2; Nagase et al (1991) and Steinhaüser et al (1985) have both been allocated a Klimisch score of 4. Hooftmann and De Wolf (2003a) is considered to be the key study for this endpoint.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

4 mg/L

Additional information

Hooftman RN & De Wolf JM (2003), was selected as the key study for this data requirement. The study was performed to current internationally accepted guidelines (OECD 203 and EU Method C.1). The study was also performed in compliance with GLP. The study was assigned a reliability score of 2 (reliable with restrictions) as there were unavoidable deficiencies present in the study in relation to the analytical methods employed in the study, however due to the physical properties of the substance, derivatisation is the most appropriate method available. The study, a semi-static acute toxicity test with the zebra fish Brachydanio rerio(TNO study number: 01-2495/03), found the test material to be not acutely toxic to the zebra fish within its aqueous solubility under the conditions of the study. The 96h LC50 is > the water solubility (average 4.0 mg.l^-1in the full study). As the solubility of the test substance is most likely higher (> 10 mg.l^-1), consequently the LC50 may also be higher as indicated by the results of the limit test and of the preliminary range-finding test. However, the results of the full study do not demonstrate this.

 

Nagase H et al (1991) and Steinhaüser K et al (1985) were provided as supporting studies. Both were assigned reliability scores of 4, as the documentation of the studies was insufficient for accurate assessment of the quality of the data.

Steinhaüser K et al (1985) , performed anacute toxicity test with the Golden Orphe, Leuciscus idus, the test material was found to have an LC50 value of 600µg/L. Method used was the German DIN 38 412, part 15.

Nagase H et al (1991) performed a semi-static acute toxicity test with the red killifish Oryzias latipes the test material was found to have a 48h LC50 value of 5.80 mg/l. The study was conducted to the OECD Guideline no. 203.