Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Reference
Reference Type:
publication
Title:
Journal of Pharmacology and Experimental Therapeutics
Year:
1930

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute dermal toxicity in rats
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Disodium hexafluorosilicate
EC Number:
240-934-8
EC Name:
Disodium hexafluorosilicate
Cas Number:
16893-85-9
IUPAC Name:
disodium hexafluorosilicate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
other: Rats were introduced in solutions of disodium hexafluorosilicate
Vehicle:
water
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LDLo
Effect level:
ca. 70 mg/kg bw

Applicant's summary and conclusion