2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)benzoic acid

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 October 1996 and 9 January 1997

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: study followed guideline from OECD andEC and in accordance with GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

PERFORMANCE OF THE TEST
Test temperature: 20°C ± 0.5°C.
A clean, dry pycnometer was accurately weighed and then filled to the limits of its capacity with distilled water. The pycnometer was left to stand for 1 hour in a water bath at 20°C. It was then carefully stoppered without trapping air, dried and re-weighed. The procedure was repeated with the same pycnometer using hexane.
To the clean, dry and accurately weighed pycnometer test substance (ca 15 g) was added. The pycnometer was re-weighed and then the test substance covered with hexane. After vigorously shaking of the stoppered pycnometer to suspend the test substance, any bubbles were removed by ultrasonifying for 5 minutes. The pycnometer was then completely filled with hexane, equilibrated and weighed as before.
Two tests were performed concurrently using separate pycnometers

GLP compliance:

yes

Type of method:

pycnometer method

Test material

Test material information

Constituent 1

Test material form:

solid: crystalline

Details on test material:

Date received:2 October 1996
Chemical class: 2-Ethoxy-5- (4methyl- l-piperazinesulphonyl) benzoic acid.
Pharmaceutical intermediate
White powder. Room temperature.

Results and discussion

Density

Key result

Type:

relative density

Density:

1.39 other: no units

Temp.:

20 °C

Any other information on results incl. tables

WEIGHINGS                    Test1                           Test2

(g)                              (g)

 

 

Pycnometer	33.8170	33.6800
Pycnometer+water	81.1546	83.8909
Massofwater	47.3376	50.2109
Pycnometer	33.8172	33.6800
Pycnometer+hexane	65.9406	67.7258
Massofhexane	32.1234	34.0458
Pycnometer	33.8162	33.6795
Pycnometer+testsubstance	49.7812	49.1568
Pycnometer+testsubstance+hexane	74.0930	75.6476
Massoftestsubstance	15.9650	15.4773
Massofhexane	24.3118	26.4908

Applicant's summary and conclusion

Conclusions:

The relative density (D o) ofUK-143,108 is 1.39