(S)-ethyl 3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate

Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Remove to fresh air and keep patient at rest. Seek medical

attention immediately.

Emergency measure - Eyes: Flush with water while holding eyelids open for at least 15

minutes.  Seek immediate medical attention.

Emergency measure - Skin: Remove contaminated clothing. Flush area with large amounts

of water. Use soap.  Seek medical attention.

Emergency measure - Ingestion: Seek medical attention immediately.

Fire-fighting measures

Recommended extinguishing agent: Water spray, foam, dry powder or carbon dioxide.

Product arising from burning: Will burn emitting toxic fumes of oxides of nitrogen, carbon

monoxide and halogen containing gases.

Product determined by test: N

Protective equipment: During all fire fighting activities, wear appropriate

protective equipment, including self-contained breathing

apparatus.

Accidental release measures

Emergency measures in case of spillage: Personnel involved in clean-up should wear appropriate

personal protective equipment. Minimize exposure.

In the event of a large spillage, non-essential personnel

should be evacuated from affected area.  Report emergency

situations immediately.  Clean up opporations should only be

undertaken by trained personnel.  Wear an air suit, rubber

gloves and rubber boots.  Collect spilled material by a

method that controls dust generation. A damp cloth or

filtered vacuum should be used to clean spills of dry

solids. Clean spill area thoroughly.  Transfer the waste

test substance to an appropriately labelled, sealed

container for disposal.  Wipe up any powder left with a damp

cloth and place in a container for disposal.  Care should

be taken to avoid environmental release.

In the event of a small spillage wear laboratory coat, eye

protection, rubber gloves and if the spillage occurs outside

a fume cupboard, a dust respirator to FFP2S protection.

Collect up the solid carefully and transfer to a sealed

container.  Wipe up any powder left with a damp cloth and

place in a container for disposal.

The material should be disposed of by incineration in a

chemical incinerator in compliance with national or regional

requirements.

Handling and storage

Handling: The material should be handled in closed containers where

possible. Otherwise use appropriate local exhaust

ventilation or perform work in a fume cupboard.  Care should

be taken to avoid the material entering the water course.

In production areas handle in closed containers or under

suitable local exhaust ventilation. Avoid generation of

dust. Wear coveralls, rubber gloves and rubber boots when

handling this material. In the event of dust generation not

adequately controlled by LEV wear and air-suit or a PVC suit

and air hood.

In laboratory areas wear safety glasses, rubber gloves and a

laboratory coat and perform operations in a fume cupboard.

Care should be taken to avoid the material entering the

water course.

Storage: Store at room temperature in properly labeled containers.

Keep away from heat, sparks and flames.

Packaging of the substance and or preparation: The material will be packed in a sealed anti-static

polyethylene bag inside a further sealed bag contained in a

fibreboard  drum.   The contents (Nett) weight of each drum

will not exceed 25Kg.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Transport: Not classified as dangerous for transport.

SpecialProvisions

Stability and reactivity

Danger other than fire: None reported.

Chemical reaction with water: None reported.

Dust explosion: The substance is an organic powder.  Most such powders have

the capacity to form potentially explosive dusts when

subject to mechanical processes.

Available test data for dust explosion risk;

Explosion severity (20 litre sphere):

Maximum explosion pressure, Pmax:7.1 barg

Kst value: 202 bar.m.S-1

St class 2 (medium explosion severity potential)

Minimum Ignition Energy: 25 - 100 mJ

Minimum (dustcloud) Ignition Temperature: 490 Deg C

Limiting Oxygen Concentration: 11.0% by volume

Dust explosion determined by test: Y

Disposal considerations

Industry - Possibility of recovery/recycling: Not applicable

Industry - Possibility of neutralisation: Not applicable

Industry - Possibility of destruction: controlled discharge: Not application

Industry - Possibility of destruction - incineration: Not applicable

Industry - Possibility of destruction - water purification: Organic waste streams are dangerous.  Aqueous waste has been

inhibited tested by the Waste Water Treatment Facilities

(WWTF) and found to send to the drain, they are then sent to

drain where they are then treated by the WWTF.

Industry - Possibility of destruction - other: Not applicable

Public at large - Possibility of recovery/recycling: Not applicable

Public at large - Possibility of neutralisation: Not applicable

Public at large - Possibility of destruction: controlled discharge: The waste water treatment plants at Pfizer Ltd, at sandwich

use a dilution factor of 100-1 as they discharge to the

local estuary (Stour Estuary, Kent UK).  At present Pfizer

Ltd, Ringaskiddy, also use a diltion ration of 100-1 as they

discharge to the local harbour (Cork Harbour, Irelend)

Public at large - Possibility of destruction - incineration: All organic and aqueous waste streams are treated and sent

to an Organic Waste Tank for incineration.  All residuals

are negligible. Flue gases are scrubbed.

Public at large - Possibility of destruction - water purification: Not applicable