3-methyl-5-phenylpentanol

Short-term toxicity to aquatic invertebrates

Description of key information

Key study:- Goodband & Mullee (2011) Acute toxicity to aquatic invertebrate (OECD 202, EPA OPPTS 850.1010 and EPA OPP 72.2): 48 hour EC50 13 mg/L (95 % CL 10-18 mg/L); 48 hour NOEC 10 mg/L; 24 hour EC50 20 mg/L
Supporting study:- Caspers (1989) Acute toxicity to aquatic invertebrate (Determination of the immobilisation of water fleas (Daphnia magna) EC 0/EC 50/EC 100/24 hours static system, German Federal Environment Agency, Berlin, May 1984); 24 hour EC50 27 mg/L (Performed on a structural analogue of 3-methyl-5-phenylpentanol).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

13 mg/L

Additional information

The key study for this endpoint, Goodband and Mullee (2011), was performed in accordance with the standardised guidelines OECD 202, EPA OPPTS 850.1010 and EPA OPP 72-2. The study was performed in line with GLP and reported to a high standard. In accordance with Klimisch (1997), the study was assigned a reliability score of 1. The 48 hour EC₅₀ was determined to be 13 mg/L with 95 % confidence limits of 10-18 mg/L. The 48 hour No Observed Effect Concentration was determined to be 10 mg/L.

Supporting information was available in the form of Caspers (1989). The study was performed on 2-methyl-5-phenylpentanol, a structural analogue of 3-methyl-5-phenylpentanol, the only difference between the two substances being the position of the methyl group. The results were included to demonstrate comparability in the acute aquatic toxicity between the two substances since data on 2-methyl-5-phenylpentanol has been used in this dossier to address the acute fish endpoint for 3-methyl-5-phenylpentanol on the basis of read-across. The study was performed in accordance with the guideline Determination of the immobilisation of water fleas (Daphnia magna) EC 0/EC 50/EC 100/24 hours static system, German Federal Environment Agency, Berlin, May 1984, which was comparable to OECD Guideline 202, except that only one observation was performed at 24 hours. The report was presented in limited detail. With these considerations, the study was assigned a reliability score of 3 in accordance with Klimisch (1997). The 24 hour EC₅₀ was determined to be 27 mg/L, this was comparable to the 20 mg/L 24 hour EC₅₀ observed in the key study performed on 3-methyl-5-phenylpentanol. This study supports the argument that data on 2-methyl-5-phenylpentan-1-ol can be used to address aquatic toxicity data requirements for 3-methyl-5-phenylpentanol on the basis of read-across.