Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 238-238-4 | CAS number: 14302-13-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
CAS 14302 -13 -7 was not mutagenic in a preincubation in a standard plate Ames test (tested up to 5000 μg/plate in Salmonella typhimurium TA1535, TA1537, TA98, TA100 and E. coli WP2 uvrA with and without metabolic activation (S9 fraction from the liver of male Sprague-Dawley rats (treated i.p. with 500 mg/kg bw Aroclor 1254, 5 days before sacrifice), mixed with a series of cofactors). Cytotoxicity was occasionally observed depending on the strain and test conditions from about 500 µg - 2500 µg/plate onward. (acc. OECD guideline 471, BASF AG 2000).
Read-across was applied for the chromosome abberration and mammalian cell gene mutation assay. The read-across justifications are attached to the robust study summaries.
Justification for classification or non-classification
No signs of genotoxic effects in-vitro were observed, neither in bacterial systems nor in mammalian cells.
Additionally, no signs of genotoxic effects in-vivo were seen, neither in the Micronucleus Test, nor in the Nucleus Anomaly Test or the Mouse Spot test.
Thererefore, there is no indication given for classification for mutagenic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
