Registration Dossier
Registration Dossier
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EC number: 610-199-1 | CAS number: 446292-04-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
4 -(4 -Nitrophenyl)-3 -morpholinon was shown to be mutagenic with and without metabolic activation in the S. typhimurium strains TA 100, TA 98 and TA 102 in a bacterial reverse mutation assay with the S. typhimurium strains TA 1535, TA 100, TA 1537, TA 98 and TA 102. The study was conducted using the plate incorporation method with substance concentrations from 50 to 5000 µg per plate.
Short description of key information:
Gene mutation in vitro (bacterial reverse mutation assay, GLP, OECD TG 471, EU Method B. 13/14, EPA OPPTS 870.5100): positive in the tested Salmonella typhimurium strains TA 100, TA 98 and TA 102
[Bayer AG, Report No. PH-34802, 2007-02-28]
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
Classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
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