2-(2-aminoethoxy)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 Mar 1969 - 19 Mar 1969

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1969

Report date:

1969

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Inhalation-Risk-Test: BASF-test, see details in remarks on material and methods

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-aminoethoxy)ethanol

EC Number:

213-195-4

EC Name:

2-(2-aminoethoxy)ethanol

Cas Number:

929-06-6

Molecular formula:

C4H11NO2

IUPAC Name:

2-(2-aminoethoxy)ethan-1-ol

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Aminodiglykol, 2-(2-Hydroxyaethoxy-)aethylamin
- Physical state: liquid
- Analytical purity: > 99 %

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 157 g (mean)

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

In the raw data no substance loss but an increase in substance weight was recorded.

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of exposure and daily thereafter
- Frequency of weighing: day 0 and day 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 8.7 mg/m³ air (nominal)

Exp. duration:

8 h

Remarks on result:

other: no mortality occured within 8h; calculation based on the saturated vapor concentration

Mortality:

No mortality occured.

Clinical signs:

other: No symptoms observed.

Body weight:

The animals gained weight.

Gross pathology:

2x bronchitis

Any other information on results incl. tables

The inhalation of a highly saturated vapour-air mixture for 8 h caused no mortality.

Calculation of the saturated vapor concenration is basd on the vapor pressure at 25°C = 0.002 hPa and the molecular weight = 105.14 g/mol which equals a sat. vapor conc. = 0.0087 mg/L = 8.7 mg/m³.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LC50 > 8.7 mg/m3

Executive summary:

The inhalation of a saturated vapor-air mixture for 8 hours caused no mortality in the inhalation risk test. No clinical signs or indications at necropsy were observed.